New Approach Quantifies the Hydraulic Permeability of Skin, Revealing the Spongelike Properties of the Dermis
A new approach to quantify the hydraulic permeability of skin reveals the spongelike properties of the dermis layer, according to a study in PNAS Nexus.
For the study, Alan J. Grodzinsky, ScD, of Massachusetts Institute of Technology in Cambridge, Mass, Gustavo S. Luengo of L'Oréal Research and Innovation in Aulnay sous Bois, France, and colleagues devised an original method for measuring skin’s hydraulic permeability.
The authors used atomic force microscopy-based nanoindentation to study 14 human skin samples with a polystyrene nano-probe and interpreted the results via a recently developed poroelastic theoretical model. This approach enabled the authors to quantify biophysical characteristics of individual layers of ex vivo human skin.
The authors found that hydraulic permeability is highest in the dermis. Much as water runs out of a sponge when it is depressed, water moves away through the tissue matrix and cells of the dermis when it is depressed—and flows backwards when the mechanical pressure is released. The stratum corneum had the least permeability, suggesting that this layer is an important barrier for water loss. According to the authors, the method can be used to assess the effect of lotions, creams, and other skin additives designed to increase the plumpness or moisturizing level of the skin.
CAPTION: Schematic representation of the skin samples used in the high-bandwidth atomic force microscopy nanorheology experiments.