Study Explores Improving Neck Laxity, Wrinkle Severity 

A new case study published in Cureus by Saami Khalifian, MD; Alec D. McCarthy, MD; and Steven Yoelin, MD, investigates the efficacy and safety of an injectable therapy to treat neck wrinkles and skin laxity by utilizing a combination of hyperdiluted calcium hydroxylapatite (CaHA), platelet-rich plasma (PRP), and hyaluronidase.

Two patients presenting with moderate neck wrinkles and laxity underwent treatment and were evaluated several months later. 

The study found the combined therapy demonstrated improvements in skin texture and laxity following a single treatment. The reasoning for incorporating PRP and hyaluronidase was the potential to amplify the regenerative effects of CaHA. PRP contains growth factors that stimulate collagen production and regeneration, while hyaluronidase facilitates the breakdown of hyaluronic acid, promoting better diffusion and even product dispersion. 

The findings from these cases provide emerging preliminary evidence supporting the safety and efficacy of this innovative combination therapy for addressing neck wrinkles and laxity. 

The researchers say this is the first documented instance of skin priming CaHA with hyaluronidase and PRP. 

Future investigations are warranted to explore the application of treatment for other anatomical regions and to delineate the role of each injected component.