In each issue, Modern Aesthetics® magazine asks top cosmetic dermatologists about the newest cosmeceuticals that they are offering to patients. Here, Jeanine B. Downie, MD, FAAD, director of image Dermatology PC in Montclair, NJ, talks about Sente’s Cyspera, a novel pigment corrector formulated with Cysteamine.

What is Cyspera?

Jeanine B. Downie, MD: Cyspera is the first topical cream containing cysteamine hydrochloride (HCI) to diminish the appearance of stubborn skin discoloration. Cyspera is formulated without hydroquinone or retinol, which makes it well tolerated for long-term use. Cysteamine delivers antioxidant activity with multiple effects on the appearance of skin discoloration.

How do you suggest your patients use Cyspera?

Dr. Downie: I am recommending it be used on the face every other night for 15 minutes when patients start the product, because sometimes it is too strong to use every night. After about a month or two, I allow them to use it for 15 minutes or more on the face. On the body, they can start using it for 30 minutes every night. I do combine it with some of the hydroquinones.

One of my favorite ways to use it is with the Obagi Vitamin C/hydroquinone serum (Obagi-C Rx System) overnight on dark patches after using the Cyspera earlier in the evening and then rinsing it off.

Who benefits from Cyspera?

Dr. Downie: All ethnicities benefit from Cyspera. I recommend this product to my white, black, Latino, and Asian patients. Everyone seems to benefit from it and likes it a lot. However, since hyperpigmentation is a real bother for more melanin-rich skin, some of my darker skin patients rely on it more.

What types of results are patients seeing with regular use?

Dr. Downie: In a pivotal trial, the investigator noticed significant improvements in the appearance of discoloration in 85 percent of subjects. In the same trial, 92 percent of users saw improvements in the appearance of brown patches.