A patent-pending topical Nitric Oxide serum may boost circulation and pro-fibroblastic-enhancing capabilities when used alone and improve absorption dynamics when combined with other products, according to a pilot study in the Annals of Plastic and Reconstructive Surgery.

Twenty five patients (20 females and 5 males) aged 32 to 81 used Pneuma Nitric Oxide's N1 O1 serum, a patent pending NO generating dual chamber mixing serum. for 12 weeks. Nitric Oxide could still be detected 30 minutes after the initial application. Moreover, there were no hypersensitivity, allergic, or irritant reactions reported by any patient.

A topical Nitric Oxide serum enhances the tone, quality and texture of skin, yielding a reduction in the appearance of fine lines, static rhytids, enlarged pores, and unwanted pigment, concludes study author Gregory Chernoff, MD, FRCS of Chernoff Plastic Surgery located in Indianapolis. When used prior to any other product, the vasodilatory property primes the skin to enhance their absorption.

Specifcally, 65 percent of patients noticed a decrease in visible wrinkles at 4 weeks, 70 percent by 8 weeks, and 87 percent by 12 weeks. Decreased pore size was reported by 50 percent at 4 weeks, 61 percent at 8 weeks, and 65 percent by 12 weeks, the pilot study showed. An increase in skin tone was perceived by 70 percent at 4 weeks, 82 percent at 8 weeks, and 85 percent by 12 weeks. Improved skin texture was noted by 72 percent at 4 weeks, 81 percent by 8 weeks, and 88 percent by 12 weeks.

Decreased pigmentation was noticed by 50 percent at 4 weeks, 62 percent at 8 weeks, and 75 percent by 12 weeks. Decreased skin oiliness was noted by 70 percent at 4 weeks, 75 percent by 8 weeks, and 83 percent by 12 weeks. Unwanted vasculature such as telangiectasia or rosacea-related erythema was improved in 51 percent by 12 weeks, the study found. By 12 weeks, 84 percent of patients were “Extremely Happy” with their results.